Gastric Acid Secretion and Experimental Ulceration in rats fed Soybean Diet Preparations

Abstract

Effects of different preparations of Soybean diet on histamine or carbachol-induced acid secretion 
and indomethacin –induced ulceration were studied in male albino Wister rats. The animals were 
divided into four dietary groups (groups I, II, III and IV) and fed normal rat diet, 75% soybean diet, 
50% soybean diet and 25% soybean diet respectively. Rats in group I served as control. After six 
weeks of feeding, acid secretion studies using histamine (3mg/Kg) or carbachol (50µg/Kg) and ulcer 
studies were carried out. While histamine and carbachol produced 400% and 350% increases 
respectively in acid output in rats fed normal diet, the acid output in soybean diet fed rats were 
between 210% and 280%. Also, rats fed soybean diets had lower ulcer scores than rats fed normal 
diet. Indeed, the higher the concentration of soybean in the diet the lesser the ulcer scores. The 
results therefore seem to suggest that soybean has buffering effect on induced acid secretion and 
protect the stomach against ulcer formation.