Optimized Qbd-Based Phytosomal Nanocarrier Of Desmodium Gangeticum For Enhanced Bioavailability And Anxiolytic Activity.

Abstract

The goal of this work is to improve the bioavailability and therapeutic efficiency of the ancient Ayurvedic herb Desmodium gangeticum (Shalparni), especially its anxiolytic potential, by creating and characterizing a novel phytosomal formulation. Limited systemic absorption and poor solubility are common problems with herbal medications. By enhancing medication distribution and membrane permeability, phytosomes—complexes of phytoconstituents and phospholipids—offer a possible remedy. The solvent injection method was used to prepare the phytosomes for this investigation, and Box-Behnken design was used to optimize the process using Quality by Design (QbD). Desired physicochemical properties, such as an 85% entrapment effectiveness, a zeta potential of 13 mV, and a particle size of 183.2 nm, were demonstrated by the improved phytosomal formulation.

A sustained drug release profile of 78.18% over a 24-hour period was found in in vitro release tests. The robustness of the formulation was validated by stability testing, and its pharmaceutical appropriateness was substantiated by solid-state characterisation and tablet formulation. These results imply that phytosomes are a practical way to get around restrictions in the delivery of herbal drugs, providing a good substitute for traditional dose forms.