Effect of T. Arjuna Stem Bark Extract on Histopathology of Liver, Kidney and Pancreas of Alloxan-Induced Diabetic Rats

Abstract

The present study examined the effect of ethanolic extract (250 and 500 mg/kg 
body weight) of Terminalia arjuna stem bark in alloxan - induced diabetic rats 
for 30 days, and its histopathological study was investigated in the liver, kidney 
and pancreatic tissues sections. Pathological lesions were evoked in cells of 
diabetic rats. The extract improve the liver, kidney and pancreas function and 
reduce lesions associated with diabetic state in alloxan induced rats. The effect 
of oral administration of T. arjuna at a dose of 500 mg / kg body weight was 
more efficacy than the 250 mg/kg body weight. The results indicate the extract 
exhibit the protective effect on tissues, and proves its potentials as an 
antidiabetic agent.