Evaluation of Diazepam-Ketamine-Pentazocine Anaesthesia in Rabbits

Abstract

Selected anaesthetic indices of the intramuscular administration of diazepam 5mg/kg followed 10 min later by 
ketamine 60mg/kg, with pentazocine 10mg/kg (D-K-P) or without pentazocine (D-K) as control, were evaluated in five healthy 
rabbits that were not undergoing any clinical procedure. Heart rate (HR), respiratory rate (RR) and rectal temperature (RT) of 
the anaesthetized rabbits were also determined over the initial 60-min period.Time to loss of the righting reflex with the D-K-P 
(1.9 ± 0.6 min) was similar to the control value of 2.0 ± 0.0 min. Whereas D-K lacked analgesic activity, the onset and duration 
of analgesia with the D-K-P were respectively 3.6 ± 1.4 min and 95.0 ± 10.6 min. Recumbency time with the D-K-P (128.6 ±
9.3 min) was significantly (P < 0.05) shorter than the control value of 184 ± 3.3 min. Time to standing with the D-K-P (17.4 ±
1.6 min ) was also significantly shorter than the control value of 42.0 ± 1.4 min. Mean HR with the D-K-P ranged between 
140.8 ± 16.1 and 166.4 ± 19.9 beats/ min and were below the control range of 188.6 ± 6.4 and 201.0 ± 3.1 beats/min. Range of 
mean RR with the D-K-P (34.4 ± 3.1 to 68.0 ± 10.7) breaths/ min was below the control range of 71.4 ± 6.9 and 121.2 ± 12.6 
breaths/min. Mean RT with the D-K-P ranged between 38.0 ± 0.4 and 39.9 ± 0.50
C and were similar to the control range of 
39.9 ± 0.10 C.It was concluded that the intramuscular administration of D-K-P at the dose rates employed in this study provided 
satisfactory immobility, analgesia and muscle relaxation of long duration, albeit with some clinically insignificant degree of 
cardiorespiratory depression, in healthy rabbits.