Modulating Action of 17β Estradiol on Urinary Volume and Renal Excretion of Some Electrolytes in Dietary Salt-fed Female Rats

Abstract

Body fluid and electrolyte balance are essential for normal cellular function, maintenance of adequate plasma volume and 
osmolality, yet natural and synthetic female sex hormones have various effects on body fluid and electrolyte balance. This study 
determined the effect of combined administration of 17β estradiol and dietary salt on some renal parameters. Thirty-two female 
Albino rats were used for this study and they were assigned into four groups consist of eight rats in each group. The group A 
served as control while groups B, C and D were given daily doses of dietary salt, 17β estradiol, and 17β estradiol with dietary 
salt respectively for four weeks consecutively. Twenty four hour urine samples were collected at the end of second and fourth 
weeks of administration for the determination of some renal parameters. The results were highly significant increase after second 
and fourth weeks for urinary volume, urinary sodium ions and chloride ion excretion, while there was significant reduction in 
urinary potassium ion excretion in groups that received dietary salt and 17β estradiol (p<0.05) when compared with the control 
group. It may be concluded that exogenous 17β estradiol administration may have some regulatory effect on body electrolytes 
and fluid in high dietary salt intake female rats.