Effects of Bonny-light Crude oil Contaminated-diet on Some Antioxidant Enzymes and Body Weight Changes of Wistar Albino Rats

Abstract

Albino rats were fed on commercial rat feeds contaminated with Bonny-light crude oil of varying concentrations of 1%, 5% and 
10% for 28 days. Feed and water were provided ad libitum throughout the experimental period. The mean body weights of the 
rats were taken one week into the treatment and at the end of the treatment. A gradual decrease in body weight was recorded with 
respect to control. A decrease in feed consumption rate with increasing concentration of the toxicant with respect to the control 
was recorded. Blood was drawn from ocular cantus vein and analyzed. A high increase in lipid oxidation, which was higher in 
males than in females, was recorded. There was a significant increase glutathione s- transferase activity in the 1% and 5% groups 
and a significant decrease in 10% group (P≤0.05). A significant increase in superoxide dismutase activity was recorded in all the 
groups with respect to the parallel control group.